Endocrine Abstracts

Background: Raised prolactin is a frequent reason for referral to endocrine clinics. Prolactinomas are the most common functioning pituitary tumours. Medical management with dopamine agonists remains the treatment of choice. MHRA advises baseline echocardiograms within 3–6 months and then 6–12 monthly in patients taking dopamine agonists due to a potential risk of cardiac valvular fibrosis though the evidence for fibrosis at endocrine doses remains limited. Aim: The ...

A previously well 26-year old male developed polydipsia and polyuria in July 2002. Cranial diabetes insipidus was confirmed on water deprivation test and hormonal profile showed testosterone deficiency. MRI showed abnormalities of the pituitary stalk with lesions in the skull. On questioning, the patient had noticed painful swellings on his scalp. This raised suspicion of Langerhans’ cell histiocytosis (LCH) and skull biopsy confirmed diagnosis. He was commenced on vasopr...

A male in his 40’s diagnosed with type 2 diabetes in 2011 (BMI:20.7kg/m2) was admitted with DKA (Dec 2018) after a period of poor glycaemic control on oral hypoglycaemic agents (Feb 2017: HbA1c-105mmol/mol, Nov 2018: HbA1c-115mmol/mol). There was dramatic improvement in glycaemic control after commencing him on subcutaneous insulin (April 2019: HbA1c-56mmol/mol). GAD65 antibodies were positive (24u/mL; normal<5u/mL) and a diagnosis of latent autoimmune diab...

Case History: A male in his 40’s diagnosed with type 2 diabetes in 2011 (BMI:20.7 kg/m2) was admitted with DKA (Dec 2018) after a period of poor glycaemic control on oral hypoglycaemic agents (Feb 2017: HbA1c-105 mmol/mol, Nov 2018: HbA1c-115 mmol/mol). There was dramatic improvement in glycaemic control after commencing him on subcutaneous insulin (April 2019: HbA1c-56 mmol/mol). GAD65 antibodies were positive (24 u/ml; normal<5 u/ml) and a diagnosis of latent a...